Chemotherapy Effectiveness and Prognosis of Gastric Cancer Influenced by PTPN11 Polymorphisms

摘要: Objective: Since gastric cancer (GC) cells exhibited higher grades of SHP-2 encoded by PTPN11 than normal cells, it would be intriguing to explore whether single nucleotide polymorphisms (SNPs) influence chemotherapy effectiveness and GC prognosis among a Chinese population. Methods: Altogether 430 late-stage patients 960 healthy controls matched with age sex were incorporated. Three SNPs (i.e. rs7958372, rs12229892 rs2301756) genotyped polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Chemotherapies cisplatin 5-fluorouracil performed for 4 cycles. Odds ratios (ORs) 95% confidence intervals (CIs) calculated using the logistic regression. Survival curves plotted Kaplan-Meier method COX proportional hazard model was used analyze independent factors prognosis. Results: For rs12229892, AA GA genotypes cause 1.60-fold increase risk in comparison homozygote GG (OR = 1.60; CI 1.23-2.07; P 0.043). Results from both 2-cycle 4-cycle suggested that significantly more effective rs2301756 compared (P H .pylori infection) on considered as positive interaction, while (AA) above parameters deemed negative interaction. Finally, differentiation degree, axillary lymph node metastasis, appeared development (all Conclusion: associated reduced better effects GC, can predictor treatment target GC.