hematologic malignancies After chronic myelogenous leukemia: tyrosine kinase inhibitors in other

T Furitsu, T Tsujimura, T Tono, H Ikeda, H Kitayama, U Koshimizu, H Sugahara, J H Butterfield, L K Ashman, Y Kanayama, Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. Journal of Clinical Investigation. ,vol. 92, pp. 1736- 1744 ,(1993) , 10.1172/JCI116761

R. Schreck, Cho Tang, A. Ullrich, Xueyan Wang, T. A. T. Fong, Y. H. Kim, W. Risau, K. P. Hirth, L. K. Shawver, G. Mcmahon, T. J. Powell, Li Sun, H. App, SU5416 Is a Potent and Selective Inhibitor of the Vascular Endothelial Growth Factor Receptor (Flk-1/KDR) That Inhibits Tyrosine Kinase Catalysis, Tumor Vascularization, and Growth of Multiple Tumor Types Cancer Research. ,vol. 59, pp. 99- 106 ,(1999)

S. Hirota, Gain-of-Function Mutations of c-kit in Human Gastrointestinal Stromal Tumors Science. ,vol. 279, pp. 577- 580 ,(1998) , 10.1126/SCIENCE.279.5350.577

Moshe Talpaz, Richard T Silver, Brian J Druker, John M Goldman, Carlo Gambacorti-Passerini, Francois Guilhot, Charles A Schiffer, Thomas Fischer, Michael WN Deininger, Anne L Lennard, Andreas Hochhaus, Oliver G Ottmann, Alois Gratwohl, Michele Baccarani, Richard Stone, Sante Tura, Francois-Xavier Mahon, Sofia Fernandes-Reese, Insa Gathmann, Renaud Capdeville, Hagop M Kantarjian, Charles L Sawyers, Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. ,vol. 99, pp. 1928- 1937 ,(2002) , 10.1182/BLOOD.V99.6.1928

T Büchner, S Schwartz, E Thiel, W D Ludwig, C Sperling, Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias Haematologica. ,vol. 82, pp. 617- 621 ,(1997) , 10.3324/%X

H Kiyoi, T Naoe, S Yokota, M Nakao, S Minami, K Kuriyama, A Takeshita, K Saito, S Hasegawa, S Shimodaira, J Tamura, C Shimazaki, K Matsue, H Kobayashi, N Arima, R Suzuki, H Morishita, H Saito, R Ueda, R Ohno, Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia. ,vol. 11, pp. 1447- 1452 ,(1997) , 10.1038/SJ.LEU.2400756

CA Westbrook, AL Hooberman, C Spino, RK Dodge, RA Larson, F Davey, DH Wurster- Hill, RE Sobol, C Schiffer, CD Bloomfield, Clinical Significance of the BCR-ABL Fusion Gene in Adult Acute Lymphoblastic Leukemia: A Cancer and Leukemia Group B Study (8762) Blood. ,vol. 80, pp. 2983- 2990 ,(1992) , 10.1182/BLOOD.V80.12.2983.2983

Pieter Peeters, Sophie D. Raynaud, Jan Cools, Iwona Wlodarska, Josiane Grosgeorge, Patrick Philip, Fabrice Monpoux, Luc Van Rompaey, Mathijs Baens, Herman Van den Berghe, Peter Marynen, Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia Blood. ,vol. 90, pp. 2535- 2540 ,(1997) , 10.1182/BLOOD.V90.7.2535

E Paietta, J Racevskis, JM Bennett, D Neuberg, PA Cassileth, JM Rowe, PH Wiernik, Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: the Eastern Cooperative Oncology Group experience. Leukemia. ,vol. 12, pp. 1881- 1885 ,(1998) , 10.1038/SJ.LEU.2401229

Brian J. Druker, Charles L. Sawyers, Hagop Kantarjian, Debra J. Resta, Sofia Fernandes Reese, John M. Ford, Renaud Capdeville, Moshe Talpaz, Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome The New England Journal of Medicine. ,vol. 344, pp. 1038- 1042 ,(2001) , 10.1056/NEJM200104053441402