The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking
作者： Chiara Francavilla , Paola Cattaneo , Vladimir Berezin , Elisabeth Bock , Diletta Ami
关键词: Receptor 、 Signal transduction 、 Cell migration 、 Proto-oncogene tyrosine-protein kinase Src 、 Fibroblast growth factor receptor 1 、 Biology 、 Fibroblast growth factor receptor 、 Cell biology 、 Endocytic cycle 、 Neural cell adhesion molecule
摘要: Neural cell adhesion molecule (NCAM) associates with fibroblast growth factor (FGF) receptor-1 (FGFR1). However, the biological significance of this interaction remains largely elusive. In study, we show that NCAM induces a specific, FGFR1-mediated cellular response is remarkably different from elicited by FGF-2. contrast to FGF-induced degradation endocytic FGFR1, promotes stabilization receptor, which recycled surface in Rab11- and Src-dependent manner. turn, FGFR1 recycling required for NCAM-induced sustained activation various effectors. Furthermore, NCAM, but not FGF-2, migration, depends on Src activation. Our results implicate as nonconventional ligand exerts peculiar control intracellular trafficking resulting specific response. Besides introducing further level complexity regulation function, our findings highlight link FGFR signaling migration critical role these events dictating evoked receptor
rupress.org
manchester.ac.uk
core.ac.uk
elsevier.com参考文章(66)
Anders, M. Hinsby, Molecular mechanisms of NCAM function. Frontiers in Bioscience. ,vol. 9, pp. 2227- 2244 ,(2004) , 10.2741/1393
Ugo Cavallaro, Joachim Niedermeyer, Martin Fuxa, Gerhard Christofori, N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling Nature Cell Biology. ,vol. 3, pp. 650- 657 ,(2001) , 10.1038/35083041
S. Werner, W. Weinberg, X. Liao, K.G. Peters, M. Blessing, S.H. Yuspa, R.L. Weiner, L.T. Williams, Targeted expression of a dominant-negative FGF receptor mutant in the epidermis of transgenic mice reveals a role of FGF in keratinocyte organization and differentiation. The EMBO Journal. ,vol. 12, pp. 2635- 2643 ,(1993) , 10.1002/J.1460-2075.1993.TB05924.X
Jane L. Saffell, Emma J. Williams, Ivor J. Mason, Frank S. Walsh, Patrick Doherty, Expression of a Dominant Negative FGF Receptor Inhibits Axonal Growth and FGF Receptor Phosphorylation Stimulated by CAMs Neuron. ,vol. 18, pp. 231- 242 ,(1997) , 10.1016/S0896-6273(00)80264-0
Ugo Cavallaro, Gerhard Christofori, Cell adhesion and signalling by cadherins and Ig-CAMs in cancer Nature Reviews Cancer. ,vol. 4, pp. 118- 132 ,(2004) , 10.1038/NRC1276
Janice L. Walker, Alaina K. Fournier, Richard K. Assoian, Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension Cytokine & Growth Factor Reviews. ,vol. 16, pp. 395- 405 ,(2005) , 10.1016/J.CYTOGFR.2005.03.003
J. E. Rabinowitz, U. Rutishauser, T. Magnuson, Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 6421- 6424 ,(1996) , 10.1073/PNAS.93.13.6421
Satyajit K Mitra, David D Schlaepfer, Integrin-regulated FAK-Src signaling in normal and cancer cells. Current Opinion in Cell Biology. ,vol. 18, pp. 516- 523 ,(2006) , 10.1016/J.CEB.2006.08.011
S. Diestel, D. Schaefer, H. Cremer, B. Schmitz, NCAM is ubiquitylated, endocytosed and recycled in neurons. Journal of Cell Science. ,vol. 120, pp. 4035- 4049 ,(2007) , 10.1242/JCS.019729
Avner Yayon, Michael Klagsbrun, Jeffrey D. Esko, Philip Leder, David M. Ornitz, Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. ,vol. 64, pp. 841- 848 ,(1991) , 10.1016/0092-8674(91)90512-W