Synthesis and Crystal Structure of 2-(4-Fluorobenzyl)-6-Phenylimidazo[2,1-b][1,3,4]Thiadiazole-5-Carbaldehyde
作者： Afshan Banu , Ravi S. Lamani , I. M. Khazi , Noor Shahina Begum
DOI: 10.1080/15421406.2010.526556
关键词: Crystal 、 Chemistry 、 Monoclinic crystal system 、 Crystal structure 、 Crystallography 、 Molecule 、 Intermolecular force
摘要: The crystal and molecular structure of 2-(4-fluoro-benzyl)-6-phenyl-imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde is described. compound crystallizes in the monoclinic space group P21/n with a = 7.419(3)A, b = 8.287(3)A, c = 25.734(10)A, β = 91.686(8)°, V = 1,581.6(10)A3, z = 4. stabilized by intermolecular C-H…N, C-H…O, C-H…F interactions.
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sci-hub.se 参考文章(17)
Andanappa K Gadad, Chanabasappa S Mahajanshetti, Sudarshan Nimbalkar, Anandkumar Raichurkar, Synthesis and antibacterial activity of some 5-guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3, 4-thiadiazole-2-sulfonamide derivatives. European Journal of Medicinal Chemistry. ,vol. 35, pp. 853- 857 ,(2000) , 10.1016/S0223-5234(00)00166-5
Hans-Christoph Weiss, Roland Boese, Hans-Christoph Weiss, Heather L. Smith, Michael M. Haley, CH···π versus CH···Halogen interactions—the crystal structures of the 4-halogenoethynylbenzenes Chemical Communications. pp. 2403- 2404 ,(1997) , 10.1039/A706564G
Gautam R. Desiraju, R. Parthasarathy, The nature of halogen.cntdot..cntdot..cntdot.halogen interactions: are short halogen contacts due to specific attractive forces or due to close packing of nonspherical atoms? Journal of the American Chemical Society. ,vol. 111, pp. 8725- 8726 ,(1989) , 10.1021/JA00205A027
Vinayak S. Hegde, Gundurao D. Kolavi, Imtiyaz Ahmed M. Khazi, Chemoselectivity of thiophene dicarboxylate towards hydrazine hydrate: Synthesis of some new bis heterocycles from thiophene monocarbohydrazide Journal of Sulfur Chemistry. ,vol. 27, pp. 307- 314 ,(2006) , 10.1080/17415990600786094
Gundurao Kolavi, Vinayak Hegde, Imtiyaz ahmed Khazi, Pramod Gadad, Synthesis and evaluation of antitubercular activity of imidazo[2,1-b][1,3,4]thiadiazole derivatives Bioorganic & Medicinal Chemistry. ,vol. 14, pp. 3069- 3080 ,(2006) , 10.1016/J.BMC.2005.12.020
C. P. Brock, M. S. Kuo, H. A. Levy, 4,4'-Dichlorobiphenyl: crystal packing in para-substituted biphenyls Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. ,vol. 34, pp. 981- 985 ,(1978) , 10.1107/S0567740878004586
D. THIENPONT, O. F. J. VANPARIJS, A. H. M. RAEYMAEKERS, J. VANDENBERK, P. J. A. DEMOEN, F. T. N. ALLEWIJN, R. P. H. MARSBOOM, C. J. E. NIEMEGEERS, K. H. L. SCHELLEKENS, PAUL A. J. JANSSEN, Tetramisole ( R 8299), A New, Potent Broad Spectrum Anthelmintic Nature. ,vol. 209, pp. 1084- 1086 ,(1966) , 10.1038/2091084A0
Aldo Andreani, Mirella Rambaldi, Giuseppe Mascellani, Pierluigi Rugarli, Synthesis and diuretic activity of imidazo[2,1-b]thiazole acetohydrazones European Journal of Medicinal Chemistry. ,vol. 22, pp. 19- 22 ,(1987) , 10.1016/0223-5234(87)90169-3
L. J. Farrugia, ORTEP-3 for Windows - a version of ORTEP-III with a Graphical User Interface (GUI) Journal of Applied Crystallography. ,vol. 30, pp. 565- 565 ,(1997) , 10.1107/S0021889897003117
Gautam R. Desiraju, The C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it? Accounts of Chemical Research. ,vol. 24, pp. 290- 296 ,(1991) , 10.1021/AR00010A002