Kaempferol inhibits fibroblast collagen synthesis, proliferation and activation in hypertrophic scar via targeting TGF-β receptor type I.

摘要: Hypertrophic scar (HPS) formation is a debilitating condition that results in pain, esthetic symptom and loss of tissue function. So far, no satisfactory therapeutic approach has been available for HPS treatment. In this study, we discovered natural small molecule, kaempferol, could significantly inhibit mechanical load-induced mouse model. Our also demonstrated kaempferol remarkably attenuated collagen synthesis, proliferation activation fibroblasts vitro vivo. Western blot analysis further revealed down-regulated Smad2 Smad3 phosphorylation dose-dependent manner. At last, found such bioactivity which resulted from the inhibition TGF-β1/Smads signaling was induced by selective binding to TGF-β receptor type I (TGFβRI). These findings suggest be developed into promising agent treatment or other fibroproliferative disorders.