Pyrrole ring opening – pyridine ring closure: Recyclization of 2-(2-oxo-1,2-dihydro-3H-pyrrol-3-ylidene)malononitriles into highly functionalized nicotinonitriles
作者： Angelina G. Milovidova , Mikhail Yu. Belikov , Mikhail Yu. Ievlev , Oleg V. Ershov , Oleg E. Nasakin
DOI: 10.1016/J.TETLET.2019.151368
关键词: Medicinal chemistry 、 Pyridine 、 Ring (chemistry) 、 Chemistry 、 Pyrrole 、 Organic chemistry 、 Biochemistry 、 Drug discovery
摘要: Abstract A series of novel N,N-dialkyl-2-amino-3-cyanoisonicotinamides were synthesized in good to high yields (61–84%) via the reaction 2-(5-aryl-2-oxo-1H-pyrrol-3(2H)-ylidene)malononitriles and amines according ANRORC process. The developed approach represents a method for synthesis functionalized nicotinonitriles.
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