Agrimonia eupatoria protects against chronic ethanol-induced liver injury in rats.
作者： Seong-Jin Yoon , Eun-Ji Koh , Chang-Soo Kim , Ok-Pyo Zee , Jong-Hwan Kwak
DOI: 10.1016/J.FCT.2012.04.005
关键词: CYP2E1 、 Immunology 、 Oxidative stress 、 Pharmacology 、 Liquid diet 、 Nitric oxide synthase 、 Liver injury 、 Agrimonia eupatoria 、 Alcoholic liver disease 、 Chemistry 、 Lipid peroxidation
摘要: This study examined the hepatoprotective effects of Agrimonia eupatoria water extract (AE) against chronic ethanol-induced liver injury. Rats were fed a Lieber-DeCarli liquid diet for 8 weeks. Animals treated orally with AE at 10, 30, 100, and 300 mg/kg/day. After consumption ethanol, serum aminotransferase activities pro-inflammatory cytokines markedly increased, those increases attenuated by AE. The cytochrome P450 2E1 activity lipid peroxidation increased after ethanol consumption, while reduced glutathione concentration decreased. Those changes Chronic levels Toll-like receptor 4 (TLR4) myeloid differentiation factor 88 protein expression, inducible nitric oxide synthase cyclooxygenase-2 mRNA nuclear translocation factor-kappa B, which was Our results suggest that ameliorates injury, protection is likely due to suppression oxidative stress TLR-mediated inflammatory signaling.
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