Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).

摘要: In humans and rodents, the entorhinal cortical (EC)-hippocampal (HPC) circuit is crucial for formation recall of memory, preserving both spatial information temporal about occurrence past events. Both modeling experimental studies have revealed circuits within this network that play roles in encoding space context. However, our understanding time-related aspects memory just beginning to be understood. review, we first describe updates regarding recent anatomical discoveries EC-HPC network, as several important neural critical been discovered by newly developed tracing technologies. Second, examine complementary multiple medial inputs, including circuits, into hippocampus memory. Finally, will discuss how contextual integrated HPC cornu ammonis 1 cells. We provide new insights mechanisms functional segregation integration networks.