A comparison of the effect of diphenhydramine and desloratadine on vigilance and cognitive function during treatment of ragweed-induced allergic rhinitis.

摘要: Background Decrements in cognitive performance are associated with the use of sedating antihistamines. Most, but not all, second-generation antihistamines have been found to be nonsedating. Objective To examine central nervous system (CNS) profile a new antihistamine, desloratadine. Methods Subjects ragweed-induced allergic rhinitis (aged 18–60 years) who demonstrated predetermined severity symptoms after priming ragweed pollen Environmental Exposure Unit were randomized receive single dose desloratadine, 5 mg; diphenhydramine, 50 or placebo. A comprehensive battery repeatable, automated neuropsychological tests was administered subjects before treatment (symptomatic baseline) and 90 minutes taking study medication. Results Both desloratadine ( P = .04) diphenhydramine Conclusions Desloratadine improved without adversely affecting performance. Diphenhydramine caused significant decrements vigilance functioning. Thus, efficacy antihistamine must balanced against effects on CNS