Systematic review and meta-analysis of mouse models of diabetes-associated ulcers

摘要: Mouse models are frequently used to study diabetes-associated ulcers, however, whether these accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed determine is in mouse of diabetes and assess the quality past research. A literature search was performed publicly available databases identify original articles examining diabetes. meta-analysis examine effect on rate using random models. meta-regression duration impairment. The included studies also assessed two newly developed tools. 77 eight different within 678 non-diabetic 720 diabetic mice were included. Meta-analysis showed that all Meta-regression suggested longer prior induction correlated with greater degree Pairwise comparisons non-obese exhibited more severe impairment compared db/db mice, streptozotocin-induced or high-fat fed at an intermediate stage (p<0.01). Quality assessment research lacked incorporation key clinically relevant characteristics. can be simulated many but require further refinement become relevant.