Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol

摘要: Cisplatin, despite its anti-cancer ability, exhibits severe testicular toxicities when applied systemically. Due to wide application in cancer treatment, reduction of damages normal tissue is an imminent clinical need. Here we evaluated the effects honokiol, a natural lipophilic polyphenol compound, on cisplatin-induced injury. We showed in-vitro and in-vivo that nanosome-encapsulated honokiol attenuated DNA oxidative stress by suppressing intracellular reactive oxygen species production elevating gene expressions mitochondrial antioxidation enzymes. Nanosome also mitigated endoplasmic reticulum through down regulation Bip-ATF4-CHOP signaling pathway. Additionally, this compound diminished breaks cellular apoptosis. The reduced type I collagen accumulation testis likely attributed from inhibition TGFβ1, αSMA ER protein TXNDC5 expression. combinatorial beneficial better preserve spermatogenic layers facilitate repopulation sperm cells. Our study renders opportunity for re-introducing cisplatin systemic therapy with toxicity restored fertility.