PGP9.5 overexpression in esophageal squamous cell carcinoma.

摘要: Background/aims PGP9.5 is a ubiquitin hydrolase widely expressed in neuronal tissue at all stages of differentiation and has been used as neuroendocrine marker. Recently, it proved that expression was highly observed squamous cell carcinoma lung cancer, suggesting might be tumor marker for carcinoma. To better characterize its role digestive tract cancers, we examined retrospectively esophageal cancers. Methodology We 40 resected cancers (squamous carcinoma) 10 gastric (adenocarcinoma) using immunohistochemistry. Results Of cancer specimens, 19 (48%) exhibited positive staining with most cells, while no any the Conclusions Although precise mechanism underlying effect on oncogenicity remains to proven, confirmed may potential