The Gastrin-Releasing Peptide Receptor as a Marker of Dysplastic Alterations in Cervical Epithelial Cells

摘要: Background: Cervical cancer is a leading in women worldwide. The Papanicolaou test (Pap test) remains the main screening tool; however, it produces high rates of false-negative and false-positive results. Gastrin-releasing peptide growth factor that has been implicated many cancers, its receptor, gastrin-releasing receptor (GRPR), nearly always expressed cervical dysplasias invasive carcinomas. aim this study was to evaluate diagnostic potential GRPR immunocytochemistry detecting dysplasia cancer. Methods: smears were collected from 66 Brazil subjected Pap test. p16 immunohistochemistry performed biopsies if abnormalities detected. Results: immunostaining sensitivity lesions 87.5% specificity 76.7%. showed 80% accuracy identifying atypical squamous cells undetermined significance (ASCUS), with 88% 71% specificity. Conclusion: This first immunocytochemical evaluation expression epithelial cells. biomarker strongly associated cancers. immunosignaling classified as ASCUS by tests. Based on these results, for may be regarded valuable method early detection intraepithelial neoplasia.