The effect of intravitreal and topical prostaglandins on intraocular inflammation

摘要: We investigated the effects of prostaglandins (PG) E2, PGD2, PG12, and its metabolites 6keto-PGE1 6-keto-PGF la, U46619 (stable analogue PG endoperoxide, PGH2) administered either intravitreally or topically on intraocular pressure (IOP), pupil diameter, aqueous protein, entry polymorphonuclear cells (PMNs) in aqueous. PGE 2, 6-keto-PGE u U46619, PGI2 increased IOP after intravitreal topical administration a dose-dependent manner, i was most potent increasing IOP. when intravitreally; however, these agents also contralateral control eye. High doses of6-keto-PGE t but not 6-keto-PGF\a orPGE 2 both experimental eyes, suggesting that this effect may be due to into systemic intraorbital circulation stimulation ofneuronal pathways. Intravitreal protein content aqueous, with j significantly more than other PGs. Topically applied x at elevated However, la did increase In contrast, PGD2 eyes; it eye, indicating are necessarily associated. None PGs tested study had any diameter PMN Therefore classic signs inflammation, i.e., IOP, miosis, associated sequential, do induce all inflammation. (INVEST OPHTHALMOL VIS SCI 23:383-392, 1982.)