Dynamic regulation of Bcl6 in follicular helper CD4 T (Tfh) cells
作者： Youn Soo Choi , Jessica A Yang , Shane Crotty
DOI: 10.1016/J.COI.2013.04.003
关键词: Cell biology 、 Immunology 、 Transcription factor 、 CD40 、 Signal transduction 、 Biology 、 Vaccination 、 Cellular differentiation 、 Germinal center 、 Cell signaling 、 BCL6
摘要: Our bodies are continuously exposed to various types of infectious pathogens. Vaccinations the most cost effective way protect our against a variety microbes. The efficacy vaccines relies on protective antibody production and generation memory B cells. These two key components develop mostly from cells that participate in germinal center reactions. Recent efforts have highlighted critical role follicular helper CD4 T (Tfh) centers. Given Bcl6 is major transcription factor for Tfh differentiation, here we review recent developments understanding signaling molecules regulate expression cells, as potential target development more efficacious vaccines.
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