Synthesis and characterisation of phosphorylcholine-based polymers useful for coating blood filtration devices

摘要: Abstract Copolymers of 2-methacryloyloxyethylphosphorylcholine (MPC) and lauryl methacrylate (LMA) molar ratios MPC : LMA x where =1, 2 or 4, have been synthesised by two different free-radical polymerisation techniques. The solubility characteristics the resulting materials were investigated in a variety water : alcohol solvent mixtures found to be influenced not only ratio MPC : LMA, but also method synthesis. A window was observed for certain copolymers alcohol used mixture profound influence on profile polymers. These soluble wider range aqueous methanol compared higher aliphatic alcohols, such as ethanol isopropyl alcohol, which rationalised terms affinity phosphorylcholine headgroup various alcohols relative water. 1 H nuclear magnetic resonance spectroscopy further examine solution properties solvents. copolymer coated onto substrates from both alcohol-only systems surface films static dynamic contact angle, atomic force microscopy (AFM) attenuated internal reflectance Fourier transform infrared (ATR-IR). coating formed hydrophilic nature, possessing spontaneous wettability, whereas solvents hydrophobic, conditioning with water more wettable surfaces attained. This phenomenon applied leukocyte filtration material, aqueous-based demonstrated lower critical wetting tension (CWST) shorter times uncoated filters those systems. haemocompatibility equivalent employed, far superior when control.