Small molecular gadolinium(III) complexes as MRI contrast agents for diagnostic imaging

摘要: Abstract Magnetic resonance imaging (MRI) contrast agents that contain the gadolinium ion are widely used in biomedical research and diagnosis. The relaxation mechanism of these T 1 -agents highlights their sensitivity towards proximal environment. Greater knowledge structurally related mechanism, particularly factors govern relaxivity, leads to scrutinized chelate designs improve enhancement. Cyclic acyclic polyaminocarboxylate complexes, especially those have favourable water exchange tumbling rate for relaxation, been reported relaxivity specificity. criteria a large gain upon protein binding, such as human serum albumin (HSA), elucidated through relaxometric study protein–chelate adduct. This adduct is an important model development agents, which may allow vivo visualization proteins. strength HSA binding observed pharmacokinetic profile give insight after intravenous administration. By using animal models, understanding physiology including biodistribution, excretion, possible site interaction, acquired. vitro studies demonstrated feasibility various disease-related proteins, cell types, gene delivery expression. Imaging at molecular level can be achieved this integrative approach incorporation nanotechnology drug delivery.