Normobaric oxygen worsens outcome after a moderate traumatic brain injury

摘要: Traumatic brain injury (TBI) is a multifaceted and leading cause of death in children, young adults, increasingly Veterans. However, there are no neuroprotective agents clinically available to counteract damage or promote repair after trauma. This study investigated the effects normobaric oxygen (NBO) controlled cortical impact rats. The central hypothesis was that NBO treatment would reduce lesion volume functional deficits compared with air-treated animals TBI by increasing oxygenation thereby minimizing ischemic injury. In randomized double-blinded design, received either (n=8) normal air TBI. Magnetic resonance imaging (MRI) performed 0 3 hours, 1, 2, 7, 14 days an primary forelimb somatosensory cortex. Behavioral assessments were before induction MRI scans on 14. Nissl staining day corroborate detected from MRI. Contrary our hypothesis, we found increased rat model moderate had positive effect behavioral measures. Our results do not acute use patients