Influence of gentamicine on the pharmacokinetic of a pentavalent antimonial compound Glucantime

作者： Laura Vásquez de Ricciardi , Nelson Vicuña-Fernández , José Vicente Scorza , Libia Vasquez , Medico Microbiologo

DOI:

关键词: Pentavalent antimonial 、 Significant difference 、 Antimony 、 Pharmacology 、 Pharmacokinetics 、 Chemistry

摘要: The pharmacokinetic parameters of Glucantime ® was studied after alone administration and in combination with gentamicine, to determine the effect aminoglucoside on plasmatic concentrations metal. Four injected dogs were used unique daily dose -1 , respectively). blood samples collected 0.25, 0.75, 1.0, 2.0, 4.0, 8.0, 12.0 24.0 hours post-treatment. Determination antimony carried out using atomic absorption spectrometer. results demonstrated that modifies depuration metal their sanguine decline resulted concentration minors. pharmacokinetics evaluated only ClB showed a statistically significant difference (0.353 ± 0.110 0.733 0.33 mL h-1kg ) suggesting minor tisular persistence when administered together gentamicine. It is important recognize future if gentamicine interferes analysis o viceversa. B

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Influence of gentamicine on the pharmacokinetic of a pentavalent antimonial compound Glucantime

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Influence of gentamicine on the pharmacokinetic of a pentavalent antimonial compound Glucantime

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