Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity.

作者: Suzanne L Topalian , Charles G Drake , Drew M Pardoll

DOI: 10.1016/J.COI.2011.12.009

关键词: AntigenPD-L1ImmunologyImmunityImmune checkpointCancer immunotherapyTumor microenvironmentT cellBiologyImmune system

摘要: … using blocking … PD-1: PD-L1 interactions appear to promote the induction/conversion and maintenance of Tregs, suggesting an additional mechanism for immunosuppression in a tumor …

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