The L-type calcium channel in the heart: the beat goes on
作者： Ilona Bodi , Gabor Mikala , Sheryl E Koch , Shahab A Akhter , Arnold Schwartz
DOI: 10.1172/JCI27167
关键词: Heart disease 、 Endocrinology 、 Atrial fibrillation 、 Internal medicine 、 Beat (music) 、 T-type calcium channel 、 Biology 、 Cardiac function curve 、 Sudden death 、 Heart failure 、 L-type calcium channel 、 Cardiology
摘要: Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that heart not beat in absence Ca2+. Fascination with role Ca2+ has proliferated into all aspects our understanding normal cardiac function and progression disease, including induction hypertrophy, failure, sudden death. This review examines L-type voltage-dependent channels disease.
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