Enhanced on-chip SERS based biomolecular detection using electrokinetically active microwells
作者： Yun Suk Huh , Aram J. Chung , Bernardo Cordovez , David Erickson
DOI: 10.1039/B809702J
关键词: Raman scattering 、 Nanotechnology 、 Chip 、 Microfluidics 、 Analyte 、 Chemistry 、 Dna viral 、 Raman spectroscopy 、 Specific detection 、 Biochemistry 、 Bioengineering 、 General chemistry 、 Biomedical engineering
摘要: A method for detecting target nucleic acids such as SNPs is provided. The comprises performing a ligase detection reaction (LDR), surface enhanced Raman scattering (SERS) on the LDR, and analyzing outcome of LDR using analysis and/or quantification SERS by an emitted signature. LDR-SERS can be used sensitive specific any acid sequence interest. microfluidic device also electrokinetically active microwells mixing concentrating analytes in which quantified. optofluidic chip format.
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