Responsiveness of dentate neurons generated throughout adult life is associated with resilience to cognitive aging.

摘要: During aging, some individuals are resilient to the decline of cognitive functions whereas others vulnerable. These inter-individual differences in memory abilities have been associated with rate hippocampal neurogenesis measured elderlies. Whether maintenance functionality neurons generated throughout adult life is linked resilience aging remains completely unexplored. Using immediate early gene Zif268, we analyzed activation dentate granule born (3-month-old), middle-aged (12-month-old), or senescent (18-month-old) rats (n = 96) response learning when animals reached 21 months age. The during developmental period was also examined. We show that adult-born can survive up 19 and 4, 10, before learning, but not developmentally neurons, activated good abilities. In contrast, aged bad do exhibit activity-dependent regulation newborn cells, whatever their birthdate. conclusion, propose responsiveness life. data add our current knowledge by showing stems only from number neurons.