Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment.
作者： Rolf Teschke , Ruediger Bahre
DOI: 10.1016/S1665-2681(19)31777-6
关键词: Psoralea corylifolia 、 Pharmacology 、 Bacopa 、 Traditional medicine 、 Eclipta 、 Medicine 、 Acacia catechu 、 Bacopa monnieri 、 Eclipta alba 、 Female patient
摘要: The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products her vitiligo and experienced causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 Bilirubin, 5.0 mg/dL). After discontinuation, rapid improvement was observed. Causality assessment the updated CIOMS (Council International Organizations Medical Sciences) scale showed probable causality (+8 points) Bakuchi tablets containing extracts from Psoralea corylifolia leaves psoralens as ingredients, primary candidate causing hepatotoxic reaction. degree probability lower +6 points other used herbs: Khadin Acacia catechu leaves; Brahmi Eclipta alba or Bacopa monnieri; Usheer tea prepared Vetivexia zizaniodis. first report being potentially in analogy to some herbs.
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