The significance of marked nuclear atypia in grade 1 cervical intraepithelial neoplasia

摘要: Approximately 10% to 15% of cases grade 1 cervical intraepithelial neoplasia are found have progressed a high-grade squamous lesion or higher at follow-up, and there presently no reliable morphological predictors this subset. It has recently been reported that display marked nuclear atypia (defined as with least 5 epithelial cells enlargement times the size an intermediate cell, and/or multinucleation nuclei.) substantially rate on short-term follow-up may, therefore, require more aggressive initial management. We report herein our experience cohort such cases. After review consecutive biopsies, 352 were classified into group (grade atypia, n = 31) 2 without 321). The average rates for groups 93.55% (29/31) 90.65% (291/321), respectively. Average durations 14.3 17.9 months, was 10.34%, compared 11.68% atypia. interpretive frequency (in cytologic samples) "low-grade lesion" significantly in 1(19/29 versus 114/291, P .009). However, significant differences identified between regarding frequencies either (3/29 34/291, 1) "negative malignancy" (6/29 56/291, .8) samples. In subsets both which high-risk human papillomavirus testing performed Papanicolaou test sample immediately preceded index viral load found. conclusion, does not than patient population. Further studies required address significance whether patients finding should be managed differently.