Integral pharmacological management of bone mineral disorders in chronic kidney disease (part I): from treatment of phosphate imbalance to control of PTH and prevention of progression of cardiovascular calcification
作者： Jordi Bover , Pablo Ureña-Torres , María Jesús Lloret , C Ruiz-García , I DaSilva
DOI: 10.1080/14656566.2016.1182155
关键词: Bone mineral 、 Atheromatosis 、 Bioinformatics 、 Secondary hyperparathyroidism 、 Kidney disease 、 Endocrinology 、 Hyperparathyroidism 、 Etelcalcetide 、 Paricalcitol 、 Internal medicine 、 Cardiovascular calcification 、 Medicine
摘要: ABSTRACTIntroduction: Chronic kidney disease-mineral and bone disorders (CKD-MBD), involving a triad of laboratory abnormalities, tissue calcifications, are associated with dismal hard-outcomes.Areas covered: In two comprehensive articles, we review contemporary future pharmacological options for treatment phosphate (P) imbalance (this part 1) hyperparathyroidism (part 2), taking into account CKD-accelerated atheromatosis/atherosclerosis and/or cardiovascular calcification (CVC) processes.Expert opinion: Improvements in CKD-MBD require an integral approach, addressing all three components the triad. Individualization P-binders combinations anti-parathyroid agents may improve biochemical control lower incidence undesirable effects. Isolated parameters do not accurately reflect calcium or P load activity stratify high risk patients CKD. Initial guidance is provided on reasonable therapeutic...
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