Gender and Cardiovascular Disease in the Post-Genomic Era

摘要: It is well established that there are sex differences in the incidence and severity of cardiac defects humans, a number clinical experimental studies it has been found estrogen may play cardioprotective role. However, large-scale randomized, double-blind, placebo-controlled hormone-replacement therapy (HRT) menopausal women, both asymptomatic women those with known coronary artery disease (CAD), results have disappointing. Alternatives to HRT sought, selective receptor modulators (SERMs) antagonist effects breast agonist heart appear be clinically safe, recently begun used. The trancriptome proteome analysis data provided important molecular information on sex-based observed pathologies. There growing evidence epigenetic environmental factors role persistent heritable changes developing fetus contribute etiology diseases might develop adulthood involved sexual dimorphism several diseases.