Insights into structure and function of 30S Ribosomal Protein S2 (30S2) in Chlamydophila pneumoniae: A potent target of pneumonia

摘要: Abstract The gene 30S ribosomal protein S2 (30S2) is identified as a potential drug and vaccine target for Pneumonia. Its structural characterization an important to understand the mechanism of action identifying its receptor and/or other binding partners. comparative genomics proteomics studies are useful 30S2 in C. Pneumoniae using different bioinformatics tools web servers. In this study, structure was modelled validated by Ramachandran plot. It found that under most favoured “core” region 88.7% overall G-factor statistics with average score −0.20. However, seven sequential motifs have been reference codes (PR0095, PF0038, TIGR01012, PTHR11489, SSF52313 PTHR11489). addition, highly conserved residues large cleft Lys160, Gly161and Arg162 volume 1288.83 A3 depth 10.75 A. Moreover, biological functions, biochemical process constituents ribosome also explored. study will be helped us sequential, structural, functional evolutionary clues unknown proteins available Pneumoniae.