Water and electrolyte movement and mucosal morphology in the jejunum of patients with portal hypertension.

摘要: Abstract Intestinal secretion and intercellular space dilatation can be induced in animal models by acute elevation of intravascular volume or portal pressure. We examined whether patients with increased venous pressure might represent a clinical counterpart to these models. Portal pressure, determined hepatic wedge measurement, was elevated 10–55 mmHg (mean 29 mmHg) 8 chronic liver disease without diarrhea. transport studies utilizing steady-state perfusion technique revealed normal absorption plasmalike electrolyte solution. A solution designed unmask intestinal demonstrated no difference from control subjects the movement water, electrolytes, protein into lumen. There correlation Jejunal biopsy significant increase spaces compared controls; this not correlated but significantly inversely plasma renin aldosterone concentration. conclude that hypertension absorb water electrolytes normally, have mild morphologic alterations mucosa, possibly related status.