Inhibitors of the anaplastic lymphoma kinase
作者： Luca Mologni
DOI: 10.1517/13543784.2012.690031
关键词: Anaplastic large-cell lymphoma 、 Targeted therapy 、 Lung cancer 、 Cancer research 、 Drug resistance 、 Receptor tyrosine kinase 、 Kinase activity 、 Crizotinib 、 Medicine 、 Anaplastic lymphoma kinase
摘要: Introduction: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine normally expressed in the developing nervous tissue. Genetic alterations of ALK are associated with number cancers, including anaplastic large cell (ALCL) and subset non-small lung cancer (NSCLC). Standard therapies for these diseases include surgery plus unspecific cytotoxic agents, low therapeutic window significant treatment-associated systemic toxicity. A few small-molecule inhibitors activity have been described recent years, some which currently undergoing clinical evaluation. Areas covered: Literature was searched all that entered investigation, published research articles meeting abstracts. Data on pharmacokinetics, safety efficacy crizotinib, as well preliminary data second-generation compounds, reviewed. The issue drug resistance discussed. Expert opinion: Understanding speci...
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researchgate.net 参考文章(83)
Lori Hudson, Kimary Kulig, Debra Young, Roger McLendon, Amy Abernethy, Abstract A42: ALK and cMET expression in glioblastoma multiforme: Implications for therapeutic targeting. Molecular Cancer Therapeutics. ,vol. 10, ,(2011) , 10.1158/1535-7163.TARG-11-A42
Xiaomu Wei, , Vijay Walia, Jimmy C Lin, Jamie K Teer, Todd D Prickett, Jared Gartner, Sean Davis, Katherine Stemke-Hale, Michael A Davies, Jeffrey E Gershenwald, William Robinson, Steven Robinson, Steven A Rosenberg, Yardena Samuels, Exome sequencing identifies GRIN2A as frequently mutated in melanoma Nature Genetics. ,vol. 43, pp. 442- 446 ,(2011) , 10.1038/NG.810
Yuyan Chen, Junko Takita, Young Lim Choi, Motohiro Kato, Miki Ohira, Masashi Sanada, Lili Wang, Manabu Soda, Akira Kikuchi, Takashi Igarashi, Akira Nakagawara, Yasuhide Hayashi, Hiroyuki Mano, Seishi Ogawa, Oncogenic mutations of ALK kinase in neuroblastoma. Nature. ,vol. 455, pp. 971- 974 ,(2008) , 10.1038/NATURE07399
Sadao Kuromitsu, Masamichi Mori, Itsuro Shimada, Yutaka Kondoh, Nobuaki Shindoh, Takatoshi Soga, Takashi Furutani, Satoshi Konagai, Hideki Sakagami, Mari Nakata, Yoko Ueno, Rika Saito, Masao Sasamata, Hiroyuki Mano, Masafumi Kudou, Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor - Cancer Research. ,vol. 71, pp. 2821- 2821 ,(2011) , 10.1158/1538-7445.AM2011-2821
Xiao-Li Du, Hai Hu, De-Chen Lin, Shu-Hua Xia, Xiao-Ming Shen, Yu Zhang, Man-Li Luo, Yan-Bin Feng, Yan Cai, Xin Xu, Ya-Ling Han, Qi-Min Zhan, Ming-Rong Wang, Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma Journal of Molecular Medicine. ,vol. 85, pp. 863- 875 ,(2007) , 10.1007/S00109-007-0159-4
Helen Y. Zou, Qiuhua Li, Joseph H. Lee, Maria E. Arango, Scott R. McDonnell, Shinji Yamazaki, Tatiana B. Koudriakova, Gordon Alton, Jingrong J. Cui, Pei-Pei Kung, Mitchell D. Nambu, Gerrit Los, Steven L. Bender, Barbara Mroczkowski, James G. Christensen, An orally available small-molecule inhibitor of c-met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms Cancer Research. ,vol. 67, pp. 4408- 4417 ,(2007) , 10.1158/0008-5472.CAN-06-4443
S. Morris, M. Kirstein, M. Valentine, K. Dittmer, D. Shapiro, D. Saltman, A. Look, Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma Science. ,vol. 263, pp. 1281- 1284 ,(1994) , 10.1126/SCIENCE.8122112
Frederic Tort, Magda Pinyol, Karen Pulford, Giovanna Roncador, Lluis Hernandez, Iracema Nayach, Hanneke C Kluin-Nelemans, Philip Kluin, Christian Touriol, Georges Delsol, David Mason, Elias Campo, Molecular Characterization of a New ALK Translocation Involving Moesin (MSN-ALK) in Anaplastic Large Cell Lymphoma Laboratory Investigation. ,vol. 81, pp. 419- 426 ,(2001) , 10.1038/LABINVEST.3780249
Jan Cools, Iwona Wlodarska, Riet Somers, Nicole Mentens, Florence Pedeutour, Brigitte Maes, Christiane De Wolf-Peeters, Patrick Pauwels, Anne Hagemeijer, Peter Marynen, Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor Genes, Chromosomes and Cancer. ,vol. 34, pp. 354- 362 ,(2002) , 10.1002/GCC.10033
Nanxin Li, Pierre-Yves Michellys, Sungjoon Kim, AnneMarie Culazzo Pferdekamper, Jie Li, Shailaja Kasibhatla, Celin S. Tompkins, Auzon Steffy, Allen Li, Frank Sun, Xiuying Sun, Su Hua, Ralph Tiedt, Yelena Sarkisova, Thomas H. Marsilje, Peter McNamara, Jennifer Harris, Abstract B232: Activity of a potent and selective phase I ALK inhibitor LDK378 in naive and crizotinib-resistant preclinical tumor models. Molecular Cancer Therapeutics. ,vol. 10, ,(2011) , 10.1158/1535-7163.TARG-11-B232