Gelation and degradation characteristics of in situ photo-crosslinked poly(l-lactide-co-ethylene oxide-co-fumarate) hydrogels
作者： Alireza S. Sarvestani , Weijie Xu , Xuezhong He , Esmaiel Jabbari
DOI: 10.1016/J.POLYMER.2007.10.007
关键词: Rheometry 、 Polymer chemistry 、 Prepolymer 、 Self-healing hydrogels 、 PEG ratio 、 Lactide 、 Kinetics 、 Materials science 、 Swelling 、 Chemical engineering 、 Macromonomer
摘要: The objective of this work was to determine the gelation kinetics, extent swelling, sol fraction, and degradation kinetics photo-crosslinked poly(l-lactide-co-ethylene oxide-co-fumarate) (PLEOF) hydrogels, with N-vinyl-2-pyrrolidone (NVP) crosslinker, as a function composition well time intensity UV radiation. process monitored by in situ rheometry. crosslinking shown be facilitated increasing NVP concentration up certain value above which hydrogel shear modulus did not increase additional amount NVP. Increasing hydrophobicity PLEOF macromer resulted decrease swelling ratio fraction due reduction apparent reactivity fumarate units. characteristics hydrogels depended on PLA PEG 30/70 (30% lactide) having highest rate.
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