Roles of PPARs in health and disease
作者： Sander Kersten , Béatrice Desvergne , Walter Wahli
DOI: 10.1038/35013000
关键词: Chronic disease 、 Nuclear receptor 、 Peroxisome proliferator 、 Diabetes mellitus 、 Physiological function 、 Biology 、 Disease 、 Bioinformatics 、 Internal medicine 、 Endocrinology 、 Peroxisome proliferator-activated receptor 、 PPAR Activity 、 Multidisciplinary
摘要: In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research …
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