Method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms)

摘要: This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example female subject. Accordingly, this provides methods of: a) treating subject suffering from cancer; b) metastatic c) refractory d) AR-positive e) f) g) and ER-positive h) triple negative i) advanced j) that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis l) prolonging survival with cancer, m) progression-free comprising administering therapeutically effective amount selective receptor modulator (SARM) compound, SARM compound invention.