Developmental changes in opiate-induced analgesia in deer mice: sex and population differences.
作者： Martin Kavaliers , Duncan G.L. Innes
DOI: 10.1016/0006-8993(90)90936-6
关键词: Biology 、 Peromyscus 、 Internal medicine 、 Opiate 、 Morphine 、 Nociception 、 Sex characteristics 、 Analgesic 、 Anesthesia 、 (+)-Naloxone 、 Population 、 Endocrinology
摘要: We examined developmental changes in nociception and mu (morphine) kappa (U-50,488) opiate-induced analgesia male female deer mice of two different populations; Peromyscus maniculatus artemisiae from a mainland region P. m. angustus small island. Both populations displayed significant morphine (10 mg/kg) U-50,488 mg/kg)-induced analgesia. Basal thermal response latencies (nociceptive responses) the levels increased over 14-35 days age, with maximum analgesic responses adults (35+ age). In both populations, young (neonatal-weaning) significantly higher greater naloxone (1.0 antagonized than females. There were also population differences analgesia, insular displaying lower animals. The evident adult sexes. These results show that there are sex mice.
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