Regulation of Organismal Proteostasis by Transcellular Chaperone Signaling

摘要: A major challenge for metazoans is to ensure that different tissues, each expressing distinctive proteomes, are nevertheless well protected at an organismal level from proteotoxic stress. We show expression of endogenous metastable proteins in muscle cells, which rely on chaperones proper folding, induces a systemic stress response throughout multiple tissues C. elegans. Suppression misfolding cells can be achieved not only by enhanced HSP90 but as effectively elevated intestine or neuronal cells. This cell-nonautonomous control relies upon transcriptional feedback between somatic regulated the FoxA transcription factor PHA-4. transcellular chaperone signaling maintains proteostasis when challenged local tissue imbalance folding and provides basis stress-sensing surveillance.