Solid Phase Synthesis of C-Terminal Boronic Acid Peptides
作者： Mira A. M. Behnam , Tom R. Sundermann , Christian D. Klein
DOI: 10.1021/ACS.ORGLETT.6B00625
关键词: Peptidomimetic 、 Yield (chemistry) 、 Chemistry 、 Solid-phase synthesis 、 Combinatorial chemistry 、 Aryl 、 Fmoc chemistry 、 Polystyrene 、 Boronic acid 、 Alkyl 、 Organic chemistry
摘要: Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis peptide-boronic acids on solid support is described here, using commercially available 1-glycerol polystyrene resin. The method compatible Fmoc chemistry offers versatile approach to aryl alkyl aminoboronic without additional purification steps.
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