No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer's disease.
作者： Eric F. Lucking , Kevin H. Murphy , David P. Burns , Anirudh V. Jaisimha , Kevin J. Barry-Murphy
DOI: 10.1016/J.RESP.2018.06.014
关键词: Breathing 、 Brainstem 、 Basal (phylogenetics) 、 Neuroinflammation 、 Respiratory minute volume 、 Genioglossus 、 Diaphragm (structural system) 、 Internal medicine 、 Control of respiration 、 Endocrinology 、 Medicine
摘要: Alzheimer's disease (AD) is a progressive neurodegenerative condition disturbing major brain networks, including those pivotal to the motor control of breathing. The aim this study was examine respiratory in TgF344-AD transgenic rat model AD. At 8-11 months age, basal minute ventilation and ventilatory responsiveness chemostimulation were equivalent conscious wild-type (WT) rats. Under urethane anesthesia, diaphragm genioglossus EMG activities similar WT duration phenylbiguanide-induced apnoea significantly shorter rats compared with WT. Following bilateral cervical vagotomy, intact Amyloid precursor protein C-terminal fragments elevated brainstem, absence amyloid-β accumulation or alterations tau phosphorylation. Brainstem pro-inflammatory cytokine concentrations not increased We conclude that neural breathing preserved at stage disease.
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