The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst

摘要: The reductive amination of ketones and aldehydes by ammonia is a highly attractive method for the synthesis primary amines. use catalysts, especially reusable based on earth-abundant metals similarly appealing. Here, iron-catalyzed amines through was realized. A broad scope very good tolerance functional groups were observed. Ketones, including purely aliphatic ones, aryl-alkyl, dialkyl, heterocyclic, as well could be converted smoothly into their corresponding In addition, pharmaceuticals, bioactive compounds, natural products demonstrated. Many groups, such hydroxy, methoxy, dioxol, sulfonyl, boronate ester substituents, tolerated. catalyst easy to handle, selective, dissolved in water employed nitrogen source. key specific Fe complex an N-doped SiC material support.