Engineered CRISPR/Cas13d Sensing hTERT Selectively Inhibits the Progression of Bladder Cancer In Vitro
作者： Yongqing Lai , Shangqi Yang , Yaoting Gui , Chengle Zhuang , Changshui Zhuang
DOI: 10.3389/FMOLB.2021.646412
关键词: Apoptosis 、 Cancer research 、 Cell growth 、 Genome editing 、 Telomerase reverse transcriptase 、 Bladder cancer 、 Cancer 、 Chemistry 、 Untranslated region 、 CRISPR
摘要: … In bladder cancer cells, hTERT ligand bound to aptamer in … induced cell apoptosis in bladder cancer 5637 and T24 cells … inhibited the progression of bladder cancer cells significantly. …
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sci-hub.st 参考文章(35)
YING-AI SHI, QIANG ZHAO, LI-HONG ZHANG, WEI DU, XUE-YAO WANG, XU HE, SHAN WU, YU-LIN LI, Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo International Journal of Oncology. ,vol. 45, pp. 1216- 1224 ,(2014) , 10.3892/IJO.2014.2493
Yuchen Liu, Yayue Zeng, Li Liu, Chengle Zhuang, Xing Fu, Weiren Huang, Zhiming Cai, Synthesizing AND gate genetic circuits based on CRISPR-Cas9 for identification of bladder cancer cells Nature Communications. ,vol. 5, pp. 5393- ,(2014) , 10.1038/NCOMMS6393
Yoko Nomura, Deepak Kumar, Yohei Yokobayashi, None, Synthetic mammalian riboswitches based on guanine aptazyme Chemical Communications. ,vol. 48, pp. 7215- 7217 ,(2012) , 10.1039/C2CC33140C
Y. Y. Chen, M. C. Jensen, C. D. Smolke, Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems Proceedings of the National Academy of Sciences of the United States of America. ,vol. 107, pp. 8531- 8536 ,(2010) , 10.1073/PNAS.1001721107
Yoko Nomura, Linlin Zhou, Anh Miu, Yohei Yokobayashi, Controlling mammalian gene expression by allosteric hepatitis delta virus ribozymes. ACS Synthetic Biology. ,vol. 2, pp. 684- 689 ,(2013) , 10.1021/SB400037A
Cora N. Sternberg, Joaquim Bellmunt, Guru Sonpavde, Arlene O. Siefker-Radtke, Walter M. Stadler, Dean F. Bajorin, Robert Dreicer, Daniel J. George, Matthew I. Milowsky, Dan Theodorescu, David J. Vaughn, Matthew D. Galsky, Mark S. Soloway, David I. Quinn, ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for Urothelial Carcinoma—Neoadjuvant and Adjuvant Settings European Urology. ,vol. 63, pp. 58- 66 ,(2013) , 10.1016/J.EURURO.2012.08.010
Chang Ho Lee, Seung Ryul Han, Seong-Wook Lee, Therapeutic Applications of Aptamer-Based Riboswitches Nucleic Acid Therapeutics. ,vol. 26, pp. 44- 51 ,(2016) , 10.1089/NAT.2015.0570
Kim Beilstein, Alexander Wittmann, Manuel Grez, Beatrix Suess, Conditional Control of Mammalian Gene Expression by Tetracycline-Dependent Hammerhead Ribozymes ACS Synthetic Biology. ,vol. 4, pp. 526- 534 ,(2015) , 10.1021/SB500270H
Michele Felletti, Julia Stifel, Lena A. Wurmthaler, Sophie Geiger, Jörg S. Hartig, Twister ribozymes as highly versatile expression platforms for artificial riboswitches Nature Communications. ,vol. 7, pp. 12834- 12834 ,(2016) , 10.1038/NCOMMS12834
Guocai Zhong, Haimin Wang, Charles C Bailey, Guangping Gao, Michael Farzan, Rational design of aptazyme riboswitches for efficient control of gene expression in mammalian cells eLife. ,vol. 5, ,(2016) , 10.7554/ELIFE.18858