Comparison of PET, CT, and Dual-Modality PET/CT Imaging for Monitoring of Imatinib (STI571) Therapy in Patients with Gastrointestinal Stromal Tumors
作者： Jörg Kanja , Andreas Bockisch , Hilmar Kuehl , Lutz S Freudenberg , Jörg F Debatin
DOI:
关键词: Stromal tumor 、 Hounsfield scale 、 Radiology 、 Imatinib mesylate 、 Response Evaluation Criteria in Solid Tumors 、 Cancer 、 Nuclear medicine 、 Medicine 、 GiST 、 PET-CT 、 Tomography
摘要: This study was implemented to compare the value of PET, CT, and dual-modality PET/CT imaging for assessing gastrointestinal stromal tumor (GIST) response imatinib therapy. Methods: Twenty patients with histologically proven GIST underwent 18F-FDG before 1, 3, 6 mo after start Separate PET CT datasets, side-by-side fused images were evaluated according World Health Organization, Response Evaluation Criteria in Solid Tumors, European Organisation Research Treatment Cancer criteria therapy response. Hounsfield units (HU) assessed on images. A mean follow-up period 381 ± 134 d served as standard reference. Results: The numbers lesions detected all 135 249 279 evaluation, 282 Tumor correctly characterized 95% 1 100% 3 PET/CT. viewed side by correct 90% at mo. accurately diagnosed 85% found be accurate 44% mo, 60% 57% HU decrease least 25% 12 14 responders Conclusion: should a combination morphologic functional imaging. Image fusion combined can provide additional information individual cases when compared CT.
参考文章(24)
Heikki Joensuu, Treatment of inoperable gastrointestinal stromal tumor (GIST) with Imatinib (Glivec, Gleevec). Medizinische Klinik. pp. 28- 30 ,(2002)
Boudewijn E. C. Plaat, Harry Hollema, Willemina M. Molenaar, Gerben H. Torn Broers, Justin Pijpe, Mirjam F. Mastik, Harald J. Hoekstra, Eva van den Berg, Rik J. Scheper, Winette T. A. van der Graaf, Soft Tissue Leiomyosarcomas and Malignant Gastrointestinal Stromal Tumors: Differences in Clinical Outcome and Expression of Multidrug Resistance Proteins Journal of Clinical Oncology. ,vol. 18, pp. 3211- 3220 ,(2000) , 10.1200/JCO.2000.18.18.3211
Andreas Bockisch, Lutz S. Freudenberg, Jörg F. Debatin, Walter Jentzen, Jörg Stattaus, Gerald Antoch, Thomas Egelhof, Focal Tracer Uptake: A Potential Artifact in Contrast-Enhanced Dual-Modality PET/CT Scans The Journal of Nuclear Medicine. ,vol. 43, pp. 1339- 1342 ,(2002)
Allan T van Oosterom, Ian Judson, Jaap Verweij, Sigrid Stroobants, Eugenio Donato di Paola, Sasa Dimitrijevic, Marc Martens, Andrew Webb, Raf Sciot, Martine Van Glabbeke, Sandra Silberman, Ole S Nielsen, Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study. The Lancet. ,vol. 358, pp. 1421- 1423 ,(2001) , 10.1016/S0140-6736(01)06535-7
Markku Miettinen, Maarit Sarlomo-Rikala, Jerzy Lasota, Gastrointestinal stromal tumors: recent advances in understanding of their biology. Human Pathology. ,vol. 30, pp. 1213- 1220 ,(1999) , 10.1016/S0046-8177(99)90040-0
Michael Y. M. Chen, Robert E. Bechtold, Paul D. Savage, Cystic Changes in Hepatic Metastases from Gastrointestinal Stromal Tumors (GISTs) Treated with Gleevec (Imatinib Mesylate) American Journal of Roentgenology. ,vol. 179, pp. 1059- 1062 ,(2002) , 10.2214/AJR.179.4.1791059
David A Tuveson, Nicholas A Willis, Tyler Jacks, James D Griffin, Samuel Singer, Christopher DM Fletcher, Jonathan A Fletcher, George D Demetri, STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications Oncogene. ,vol. 20, pp. 5054- 5058 ,(2001) , 10.1038/SJ.ONC.1204704
Thomas Beyer, Gerald Antoch, Todd Blodgett, Lutz F. Freudenberg, Tim Akhurst, Stephan Mueller, Dual-modality PET/CT imaging: the effect of respiratory motion on combined image quality in clinical oncology. European Journal of Nuclear Medicine and Molecular Imaging. ,vol. 30, pp. 588- 596 ,(2003) , 10.1007/S00259-002-1097-6
P. E. Kinahan, D. W. Townsend, T. Beyer, D. Sashin, Attenuation correction for a combined 3D PET/CT scanner Medical Physics. ,vol. 25, pp. 2046- 2053 ,(1998) , 10.1118/1.598392
Michael K. Gould, Courtney C. Maclean, Ware G. Kuschner, Chara E. Rydzak, Douglas K. Owens, Accuracy of Positron Emission Tomography for Diagnosis of Pulmonary Nodules and Mass Lesions JAMA. ,vol. 285, pp. 914- 924 ,(2001) , 10.1001/JAMA.285.7.914