Calpain and photoreceptor apoptosis.
作者： Anh T. H. Nguyen , Matthew Campbell , Paul F. Kenna , Anna-Sophia Kiang , Lawrence Tam
DOI: 10.1007/978-1-4614-0631-0_69
关键词: Caspase 、 Blood-retina barrier 、 Calpain 、 Retinitis pigmentosa 、 Biology 、 Cell biology 、 Apoptosis 、 Retinal degeneration 、 Cell survival
摘要: Photoreceptor apoptosis is present in various retinopathies such as retinitis pigmentosa and glaucoma where caspases are generally considered to be the main executioners of tissues. However, accumulating evidence suggests could occur a caspase-independent fashion. In this view, many studies have shown that calpain activation associated with photoreceptor animal light-induced retinal degeneration models. Thus, potential target for treatment may promote cell survival cases caspase inhibition has failed. Herein, we review current thinking on topic also data showing protection photoreceptors by systemic delivery inhibitor model modulation inner blood retina barrier (iBRB).
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