Phosphate—a poison for humans?

摘要: Maintenance of phosphate balance is essential for life, and mammals have developed a sophisticated system to regulate homeostasis over the course evolution. However, due dependence elimination on kidney, humans with decreased kidney function are likely be in positive balance. Phosphate excess has been well recognized as critical factor pathogenesis mineral bone disorders associated chronic disease, but recent investigations also uncovered toxic effects cardiovascular aging process. Compelling evidence suggests that increased fibroblastic growth 23 parathyroid hormone levels response contribute adverse clinical outcomes. These insights support current practice managing serum patients advanced although definitive these lacking. Given potential toxicity phosphate, general population may viewed target management. widespread implementation dietary intervention not warranted limited impact intake metabolism Nonetheless, increasing incidence disease or injury our society emphasizes importance this issue. Further work needed more completely characterize establish optimal therapeutic strategy population.