Limitation of exercise tolerance in chronic heart failure: distinct effects of left bundle-branch block and coronary artery disease.

摘要: Abstract Objectives The aim of this study was to identify resting measurements left ventricular (LV) function that predict exercise capacity in dilated cardiomyopathy (DCM); particular, the effects bundle branch block (LBBB), coronary artery disease (CAD), and total isovolumic time (t-IVT). Background t-IVT is a major determinant cardiac output during dobutamine stress DCM, itself determined by presence or absence LBBB CAD. Methods A 111 patients with 51 CAD (29 LBBB), 60 without (30 LBBB) were studied echocardiography cardiopulmonary testing. (in s/min) measured Doppler echocardiography, maximal oxygen consumption (peak Vo2) percentage normal predicted peak Vo2(%predicted obtained from Results Left reduced Vo2(by 10.5 ml·kg−1min−1) %predicted 33%, both p Conclusions Resting less prominently, CAD, are determinants tolerance DCM. significantly determines thus Vo2. Prediction maximum DCM therefore possible time-domain analysis LV at rest.