Understanding the Use of Light to Control the Circadian Pacemaker in Humans

摘要: Bright light can make large changes in the amplitude of circadian rhythms as well shift their phase. When is much reduced, phase shifting ability greatly enhanced, a manner which most readily comprehended by means vector diagrams. To obtain shifts, used effectively when stimulus reduces at beginning episode. Stimulus strategies embody strong (Type 0) resetting be very powerful, but to work they require careful adherence regimen extended exposures. A complete inversion rhythm (a 12 hour shift) possible with 10,000 lux episodes 8 hours duration or 6 on two successive days. Briefer exposures producing succession small shifts (cumulative type 1) achieve same result may several more