The influence of age on serum concentrations of cardiac troponin I: results in rats, monkeys, and commercial sera.
作者： Eugene H. Herman , Alan Knapton , Yongmin Liu , Steven E. Lipshultz , Joel Estis
关键词: Fetus 、 Apoptosis 、 Immunoassay 、 Endocrinology 、 Fetal bovine serum 、 Medicine 、 Internal medicine 、 Myocyte 、 Myofibril 、 Patas monkey 、 Troponin I
摘要: Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence age on concentrations cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys different ages. mean were highest 10-day-old compared 25-, 40-, 80-day-old SD rats. Cardiomyocyte remodeling apparent hearts from evident by hypercellularity, irregularly shaped nuclei, moderate numbers myocytes undergoing mitosis apoptosis. concentration 5 newborn considerably higher than that three 1-year-old monkeys. Evidence cardiomyocyte also observed these (loss myofibrils cytoplasmic vacuolation). Commercial animal samples analyzed. detected fetal equine porcine found adult Likewise, bovine had (>2,400 pg/ml) did caprine laprine (2.5-2.7 pg/ml). present age-related differences concentrations, with levels occurring at younger This effect consistent across several species.
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