Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects.
作者： Masaaki Yoshikawa
DOI: 10.1016/J.PEPTIDES.2015.07.013
关键词: Receptor 、 Opioid peptide 、 Agonist 、 Endogeny 、 Rubiscolin 、 Biology 、 Egg protein 、 Ligand (biochemistry) 、 Biochemistry 、 Neurotensin
摘要: We have found various bioactive peptides derived from animal and plant proteins, which interact with receptors for endogenous such as opioids, neurotensin, complements C3a C5a, oxytocin, formyl etc. Among them, rubiscolin, a δ opioid peptide RuBisCO, showed memory-consolidating, anxiolytic-like, food intake-modulating effects. Soymorphin, μ β-conglycinin anorexigenic, hypoglycemic, hypotriglyceridemic β-Lactotensin β-lactoglobulin, the first natural ligand NTS2 receptor, hypocholesterolemic Weak agonist C5a were released many proteins exerted central Peptides showing anxiolytic-like antihypertensive anti-alopecia effects via different types of OT, FPR AT2 also obtained. Based on these study, new functions post-receptor mechanisms receptor commom to exogenous been clarified.
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