Transcriptional activation by tetracyclines in mammalian cells

作者: M Gossen , S Freundlieb , G Bender , G Muller , W Hillen

DOI: 10.1126/SCIENCE.7792603

关键词: Molecular biologyGene expressionTransfectionTransgeneDoxycyclineTransactivationTranscription factorGeneBiologyMutant

摘要: A transcriptional transactivator was developed that fuses the VP16 activation domain with a mutant Tet repressor from Escherichia coli. This transactivator requires certain tetracycline (…

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