Antimicrobial Activity of Divaricatic Acid Isolated from the Lichen Evernia mesomorpha against Methicillin-Resistant Staphylococcus aureus
作者： Jong Oh , Yi Kim , Hyo-Seung Gang , Jin Han , Hyung-Ho Ha
DOI: 10.3390/MOLECULES23123068
关键词: Minimum inhibitory concentration 、 Vancomycin 、 Staphylococcus aureus 、 Enterococcus faecium 、 Methicillin-resistant Staphylococcus aureus 、 Antimicrobial 、 Chemistry 、 Agar diffusion test 、 Microbiology 、 Staphylococcus epidermidis
摘要: One hundred and seventy seven acetone extracts of lichen 258 ethyl acetate cultured lichen-forming fungi (LFF) were screened for antimicrobial activity against Staphylococcus aureus Enterococcus faecium using a disk diffusion method. Divaricatic acid was isolated from Evernia mesomorpha identified by LC-MS, ¹H-, 13C- DEPT-NMR. Purified divaricatic effective Gram + bacteria, such as Bacillus subtilis, epidermidis, Streptococcus mutans, faecium, with the minimum inhibitory concentration (MIC) values ranging 7.0 to 64.0 μg/mL, whereas vancomycin in MICs 0.78 25.0 μg/mL. Interestingly, antibacterial higher than S. epidermidis E. active Candida albicans. In addition, (3A048; an MRSA). These results suggested that is potential agent treatment MRSA infections.
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