Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation.
作者： Yasuo Kokubo , Kenzo Uchida , Shigeru Kobayashi , Takafumi Yayama , Ryuichiro Sato
关键词: Granulation tissue 、 Immunohistochemistry 、 Medicine 、 Basic fibroblast growth factor 、 Anatomy 、 Osteoarthritis 、 Vascular endothelial growth factor 、 Cervical vertebrae 、 Infiltration (medical) 、 Pathology 、 Intervertebral disc
摘要: Object In this paper the authors' goal was to identify histological and immunohistochemical differences between cervical disc herniation spondylosis. Methods A total of 500 intervertebral discs were excised from 364 patients: 198 patients with 166 We examined en bloc samples endplate-ligament-disc complexes. Types graded degrees degeneration on MR images histologically immunohistochemically. Results The herniated showed granulation tissue, newly developed blood vessels, massive infiltration CD68-positive macrophages, which surrounded tissue mainly in ruptured outer layer anulus fibrosus. vascular invasion most significant uncontained (extruded)-type discs. Chondrocytes positive for matrix metalloproteinase (MMP)–3, tumor necrosis factor (TNF)–α, basic fibroblast growth (bFGF), endothelial (VEGF) abundant...
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