Membrane Remodeling Induced by the Dynamin-Related Protein Drp1 Stimulates Bax Oligomerization

作者: Sylvie Montessuit , Syam Prakash Somasekharan , Oihana Terrones , Safa Lucken-Ardjomande , Sébastien Herzig

DOI: 10.1016/J.CELL.2010.08.017

关键词: CardiolipinCytochromeDynaminCell biologyGTPaseMitochondrial fissionProgrammed cell deathBiologyCytochrome cMitochondrial apoptosis-induced channel

摘要: … to require Drp1, a large GTPase of the dynamin superfamily. Loss of Drp1 leads to decreased cytochrome c release by a mechanism that is poorly understood. Here we show that Drp1 …

参考文章(55)
Harma Ellens, Joe Bentz, Francis C. Szoka, H+- and Ca2+-induced fusion and destabilization of liposomes Biochemistry. ,vol. 24, pp. 3099- 3106 ,(1985) , 10.1021/BI00334A005
Michael Lutter, Min Fang, Xu Luo, Masahiro Nishijima, Xiao-song Xie, Xiaodong Wang, Cardiolipin provides specificity for targeting of tBid to mitochondria. Nature Cell Biology. ,vol. 2, pp. 754- 756 ,(2000) , 10.1038/35036395
D Ardail, P Louisot, F Lerme, J P Privat, C Levrat, M Egret-Charlier, Mitochondrial contact sites. Lipid composition and dynamics. Journal of Biological Chemistry. ,vol. 265, pp. 18797- 18802 ,(1990) , 10.1016/S0021-9258(17)30583-5
Marilyn Leonard, Byeong Doo Song, Rajesh Ramachandran, Sandra L. Schmid, Robust colorimetric assays for Dynamin's basal and stimulated GTPase activities Methods in Enzymology. ,vol. 404, pp. 490- 503 ,(2005) , 10.1016/S0076-6879(05)04043-7
Guido Kroemer, Lorenzo Galluzzi, Catherine Brenner, Mitochondrial Membrane Permeabilization in Cell Death Physiological Reviews. ,vol. 87, pp. 99- 163 ,(2007) , 10.1152/PHYSREV.00013.2006
Anna Colell, Jean-Ehrland Ricci, Stephen Tait, Sandra Milasta, Ulrich Maurer, Lisa Bouchier-Hayes, Patrick Fitzgerald, Ana Guio-Carrion, Nigel J. Waterhouse, Cindy Wei Li, Bernard Mari, Pascal Barbry, Donald D. Newmeyer, Helen M. Beere, Douglas R. Green, GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation Cell. ,vol. 129, pp. 983- 997 ,(2007) , 10.1016/J.CELL.2007.03.045
Hitoshi Nakatogawa, Yoshinobu Ichimura, Yoshinori Ohsumi, Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion Cell. ,vol. 130, pp. 165- 178 ,(2007) , 10.1016/J.CELL.2007.05.021
Martin Ott, Erik Norberg, Katharina M. Walter, Patrick Schreiner, Christian Kemper, Doron Rapaport, Boris Zhivotovsky, Sten Orrenius, The Mitochondrial TOM Complex Is Required for tBid/Bax-induced Cytochrome c Release Journal of Biological Chemistry. ,vol. 282, pp. 27633- 27639 ,(2007) , 10.1074/JBC.M703155200
Yang-ja Lee, Seon-Yong Jeong, Mariusz Karbowski, Carolyn L. Smith, Richard J. Youle, Roles of the Mammalian Mitochondrial Fission and Fusion Mediators Fis1, Drp1, and Opa1 in Apoptosis Molecular Biology of the Cell. ,vol. 15, pp. 5001- 5011 ,(2004) , 10.1091/MBC.E04-04-0294
Antonio Ortiz, J. Antoinette Killian, Arie J. Verkleij, Jan Wilschut, Membrane Fusion and the Lamellar-to-Inverted-Hexagonal Phase Transition in Cardiolipin Vesicle Systems Induced by Divalent Cations Biophysical Journal. ,vol. 77, pp. 2003- 2014 ,(1999) , 10.1016/S0006-3495(99)77041-4